This can get complicated. Manufaturers use stepped headers to decrease reversion (exhaust gases sneaking back into your combustion chambers) which robs your engine of power. There is no single answer, my opinion is to use a matched system (headers and slipons from same manufacturer) and then get the bike tuned corectly after all your mods that affect your air fuel ratio are completed. Read up on reversion, scavenging, valve overlap, back pressure (tq vs hp) if you want to dive in further. All the stuff you read about 2 into 1 crossover headers vs TD's, stepped vs non-stepped etc etc is oversimplification. The best answer is your setup is always different from bike to bike. The air intake, ecu maps, exhaust system, Cam profile and compression all work together in your harley v twin to give you lowend tq and high end hp.