The combo you mention of Power Dual headpipe and Crushers are probably the tuners/builders choice around here for a near perfect combo.
I think that a 2-1 on the more modern engines are not what they used to be on the older ones. I still hear of tuning issues, and am willing to bet there is not a whole lot of difference, if any, when compared against the 2-1-2 headpipe and good mufflers.
I'm in the same boat as you. My heads and cylinders are at GMR for his 113 kit, head rebuild and porting. I will be adding the GMR 600 cam, and 58 mm TB and 5.3 injectors. Every now and then I too consider going with the Dragula or Wrath, but I don't think I would benefit, except for a different sounding exhaust.
I presently run the Fullsac DX and 4" Rineharts. I LOVE the sound, but I also own a pair of my OEM CVO mufflers with 2" Fullsac cores, which everone suggests I put on instead of the Rineharts.
By the middle of April, I will put to rest any debate on this muffler question. I will have the bike dyno tuned with both mufflers, then decide which one to go with. If the Fullsac's blow away the Rineharts low end torque wise, I'll have to give them the nod. Any less of a contest than that, I will keep my Rineys.