Hi efrbc1,
I will hop in and say that the offset in the front wheel is not helping the situation but there may be other causes and that can only be determined after a serious alignment session checking everything including the swing arm pivot, fork crown, the fork itself for play in the bushings, check chassis vertical alignment for twist, the rear wheel may be offset also, so keep track of all the numbers and soon you will have a clear picture of how that particular chassis is set up. The factory manual is your friend.
I would think that there would be symptoms when riding hard like pushing (understeer) on turns to the right and feeling somewhat different on left hand turns where the bike likes to fall in and track better.
I don't know how the bike is loaded on trips or his riding style, all have an effect on tire life as you already know.
Let me close by saying that taking the offset out of a Harley chassis can be expensive, time consuming and of little real world benefit unless you ride like a madman or have OCD, also with the offset removed the motorcycle will list slightly toward whatever side is heavier when going straight.
Ride Safe And Best Wishes: Mike