While I can't attest to any unique issues that your install will bring, I can comment on a few things that will probably still hold true for you.
1. The NIM module listens for a signal from the Road Tech only version of the Zumo to determine when to inject it's audio stream into the radio via the bluetooth phone channel. (Seems in some bikes, this is done via the comm channel - e.g. the RG but I can't confirm 100%). This audio is mono by nature and is intended only for the voice navigation prompts to interupt any audio source.
2. To continue to get stereo audio from the 665 like XM, MP3, etc... you will need to run the audio output from the gps harness to the aux input on your stereo. If you chose to modify your radio to add the aux input in the rear, you will still need to either plug the aux line with a dummy plug or sever the trace (confirm before modifying your equipment) so that the aux line is selectable.
3. Since the NIM listens to the audio stream for a signal, it can at times interpret music signals as the interruption signal and switch from a nice stereo stream to mono and then back. Not so bad if your listening to the 665; however, if you are listening to XM and then switch to say CD and forget to pause XM, this can cause it to switch to a mono xm stream for an undetermined duration. Moco's official response is to mute the GPS music when not listening to it. Otherwise, bugs and all, it still is nicer to have nav prompts when listening to a source other than the 665.
4. If you have an amp wired to the tourpack, the NIM may cause a ground loop and will require a ground loop isolator to reduce the unacceptable noise level it introduces into the aux line. The radio shack variety worked fine in my case.
Good luck, all bugs aside, still better than nothing.