I would expect you to be far from 12.1 unless all you were doing is running Wide Open Throttle.
You will most likely want something around 14:1 in low throttle cruising 13.7 - 13.4 somewhere in the middle and around 13-12.5 for 80 to 100 percent. There are VARIANCES here based on Volumetrics, Heads, Cams, timing etc and the way your tuner wants to tune the bike.
Granted Harley base maps are lean to get by EPA as a trade off from Noise / Pollution, but they still not a bad starting point to get from once and I repeat once you get the volumetrics correct for the cylinders.
What hardware do you plan on using to tune your bike to get an acceptable map setting?
There are many threads discussing these if you use the search, but here is the basic low down
SERT map changes are written directly to the ECM
Power Commanders map is based off whatever is in your ECM already with the changes happening at the PC
Thundermax is a complete ECM change with their own maps that you download into your ECM
Datyona Twin Tec compelte replacement ECM that needs a base map put in.
Fuelers / Race Paks / DFO's are add ons that go on top of the your system and add fuel