OK here I go again. There are plenty of posts about this problem on line but I will answer it again.
First thing to cover is the Navigation Interface Module (NIM). The CVO's come with it factory installed. The NIM is what is responsible for the interruption of the radio and allowing you to hear a turn prompt when one is available from the GPS. The NIM will then return the radio back to it's original mode after the turn prompt. The NIM does not do any thing else (at least it's not supposed to). At times the NIM will malfunction and do a few weird things, one of them is activating the microphone during a turn prompt. The other is that it will activate even though there is no turn prompt available, when it does this it will lock up the radio and you will have to turn the bike off and then back on to reset it.
Most Harley mech's have no idea of the proper operation of the NIM so don't blame them for not being able to troubleshoot the problems.
The NIM should not activate your microphone for any reason at any time, it is not designed to do this. Especially during a turn prompt as this defeats the purpose of having the NIM in the first place. Remember the NIM is designed to deactivate other functions of the radio so that you can hear the turn prompt. If the intercom is activated (which is what is happening) then the volume of all other radio modes is reduced so that you can hear the other person (intercom). Since the intercom is being activated the volume of the turn prompt is reduced, and you hear mostly wind noise from the microphone and you end up missing the turn prompt.
When the NIM starts doing this it is on it's way out, it's just a matter of time.
Convincing the tech to replace it under warranty (if it's still covered) is at times difficult. As I said tech's are not trained in the electronics on these bikes, it's difficult to even find someone at the Harley Mother Ship that does.
You can get a bad NIM which just came out of the BOX. I had one customer whom I helped with this issue by speaking with his dealer and they ended up replacing the NIM two times because the first brand new one did the same thing right out of the box.
Jim@hdbomm.com
In short your NIM is bad and needs to be replaced.