The answer you will get most will be........yes, but it has 4 wheels. Same principle, have you ever had a plug/patch fail?
Last year, good friend, small deck screw, center of rear tire.  Blew out a plug.  As in, no plug left in tire.  Plugged again.  Blew out again.  At 50 mph.  I was riding with him.  We pulled the tire off.  Looked shredded somewhat on the inside - cords on the inside of tire.  Very small hole, tire had about 500 miles.
Also know folks who have put thousands of miles on a plugged tire with no issues.  And know a few folks who had plugs fail after 100 miles or less.  
Old days we just patched the hole & ran a new or a patched tube.  But the bikes weighed a lot less & *ahem* so did the riders.
So it is as it is with yes/no helmet, polish/wax, oil, the magic elixer of nitrogen, and semi synthetic blinker fluids: to each their own & ride happy. 
