Thanks HOGMIKE. I was actually referring to the discussions regarding "new" narrow band O2 sensors on the 2010 CVO's in order to keep the AFR's lean and EPA legal. It seemed to be implied that the 2010's have new O2 sensors that make it difficult to lower the AFR in the closed loop configuration. On the 2010 CVO 110CI moto can I run the Fullsac baffels, cut the CAT out, and use a SE pro tuner to bring the AFR down high 13's-low 14's with the stock O2 sensors? Hell, I'm a bright guy but the more I read the more scrambled in the head I get 
Instead of trying to get "high 13's-low 14's" on your AFR it would probably be better to get it on a dyno. and find out what it "needs" to make good power/torque.
Use whatever tuner you wish with the goal of having your engine run "optimized" across the range of load/RPM.
To answer your original question: With the TTS (and, I think the ssert) it's possible to change the "AFR" (actually Lambda) in the closed loop area within a certain range.
There has been no issues with the new 2010 o2 sensors and getting the bike to perform as desired. This is with 3 of our bikes here that are 2010. All these bikes are running the Fullsac baffles, SE air filter, TTS tune, but they vary a little due to different cams and compression ratios, but, they all run great!
I'm not sure how much of a change you can make to the tables in open loop, but, that actually defeats the purpose of having the sensors to begin with!
I suggest you give Steve G. a call at Fullsac, and if you
really want to know how the tuners work, give Steve C. a call at TTS....just depends how deep you want to get into the bikes computer!
I hope this helps a little.