With careful planning you can retain good low speed manors and torque, lower temps, and still have the motor pulling at 5,500 where the stock TB signs off.
The dyno tune needs to be very comprehensive to end up with not only high maximum output but more importantly a good running bike that is happy (not pinging, cool running, and gets good mileage). WOT is just a snapshot of that mode and not where we spend most of our time. Even with closed loop the VEs need to be corrected on the individual cylinders in all operating ranges and loads, the CLB adjusted, the timing tweaked for the build. A motor with 40° overlap VS negative overlap camshaft will have a lot different needs in all aspects of operation.
The Axtell parts are a wise upgrade, headwork is smart as well just to get rid of the factory defects and ACR issues first then go after some airflow issues these heads have.
I feel bad for the owners of these bikes that have to go through all of that just to get a good running bike that doesn't ping itself to death and run hot plus is fun to ride, especially after spending a premium.