Some would say yes, others would say no. I adhere to the good/better/best theory, where stock is good, SE Street tuner is better, and a flash tuner, like the TTS Mastertune, is best.
The stock ECM was programmed to maintain stock performance, with stock components, within the EPA/DOT limits. Good.
SE Street Tuner has a tune for the ECM with those slip on mufflers, still maintaining the EPA/DOT limits, but has limited adjustability and speed governors. Better.
Flash tuners allow for much broader adjustment of the ECM parameters, and calibration ability to match most any mods and components selected. Best.
Your $, your choice. I'm sure there are guys here who would help you spend it.