99,
I have a 2020 CVO RG with the Boom Audio Stage 2 system.  I've just blown my second saddlebag speaker in 6 months so I've been researching aftermarket options.  While the dealer will give me a 1-year warranty and replace the current damaged speaker (and will check the flash), here's what I found and what I plan to do if this becomes persistent and/or I run out of warranty support:
1.  The RF TMS57 is NOT compatible with the Boom 2.  I called the RF tech and he told me absolutely not regardless of what some sites (Crutchfield) advertise.  He DID direct me to an actual drop in bi-amp replacement...
2.  The Cicada CXX57.2 is a direct replacement.  I called their tecch and asked about the bi-amp and Boom 2 compatibility.  Not only is it compatible but has the HD connections for a true drop-in replacement.
https://www.cicadaaudio.com/product/cxx57-2-speakers/I post this here as many don't want to rip out the Boom 2 and go all in with another system (like me).  Note: I have not checked the veracity nor quality of the product but put this out there for anyone wanting an option on their OEM Boom 2 system.  If you do go this route, I'd be interested to know your experience and thoughts.