I've seen the Shuttle launch live and up close twice, there is nothing like it in the world.
It is one of the "must see" things you should do once in your life. Only problem is that it only last for 90 seconds, then you have to watch on the screen.
After seeing the Shuttle I only wished I could have seen the Saturn V
And if you can't see the Shuttle live, go to this site
http://spaceflight.nasa.gov/realdata/sightings/index.htmlFill in your location you will get a chance to see it.
ISS is the International Space Station.
Last month we got to see the Shuttle following the ISS after undocking.
Tonight the Shuttle will be a minute or 2 behind the ISS.
Really cool.