I agree about factory engines. I might as well be specific now. What about a hand-built, Timken bottom end, S&S crank, 110" custom engine, getting ready to be completed? Thanks Jerry. 
Hoist! 
I forgot to mention one reason that using dino oil for initial fill makes sense; if you intend to dump the initial fill after 50 or even 500 miles, it's a lot less expensive than dumping 4 quarts of the high priced stuff. What you are basically doing with this type of break-in is using the initial fill oil to perform a final cleaning of the engines interior. If your engine was machined properly and cleaned properly prior to assembly, shouldn't be necessary to dump the oil that early.
Actually Howie, after all you've gone through you may want to use the old style break-in routine. It may be worth it just for peace of mind. Start out with dino oil, go through the heat soak routine with at least 3 repetitions, dump the oil and filter. Fill with dino oil, run at varying throttle/load settings for 50 miles, dump oil and filter. Fill with dino oil, run at varying throttle/load settings for 500 miles, dump oil and filter. Retorque head bolts and critical fasteners, fill with synthetic oil, ride normally (well, normal for most of us anyway). That is one variation, I believe S&S has their version posted on their web site.
Good luck my friend, I wish you only the best with your new 110. Assuming this build fixes all the issues, and I have reason to believe it will, you should finally get to enjoy your SERK.
Jerry