Good info thus far. As a long haul trucker during the week I can relate to many points noted above. I average 700 miles a day and as noted above start the day early and get off the road As soon as practical after dark. Also watch early afternoon - 1-3pm tends to be a dangerous time for getting tired, sneaks up on you! Plan your miles and daily goal destinations ahead, I often have my trips planned out 2 days out when on the road - usually conservative goals so I end each day in a bonus zone, once I make that bonus zone (knowing I am ahead of plan) I relax knowing I can stop as needed. Sometimes the body just needs a break, listen to it, your the boss so you can cut it short, make it a quick break, even a 20 minute nap on a picnic table has been a lifesaver and refresher for me in the past - full leathers, helmet on just laid down, don't get comfortable or you'll sleep longer and lose the benefit of a "nap". That plan ahead thing should highlight any large cities and work them in the plan to avoid rush hours or you will lose lots of time and fatigue much quicker. If your gonna hit Indianapolis at 5:00pm, stop outside town, get a bite to eat fill up and relax, then pass thru later - save your sanity, get a good late leg of the trip in, and be in better shape in the long run, by the same token if you can get through a big city at the end of the day - do it - avoid the morning rush, sleep in the next morning and be ahead of the game. - don't eat at the end of the day, eat early - ride later, rest better. More quick stops better than pushing longer - just keep them quick - (5) 5 minute quick stretch stops = 1 30 minute stop - but will give your body 5 times the refreshment - its like an athelete - a quick stop keeps you warmed up - tak an hour off you will cool down and tighten up - tight sore back/leg muscles are the enemy. Good luck - ride safe!