Base stocks are classified into five groups. Conventional motor oil is comprised of Group I and II oils. Synthetic Blends are comprised of Groups III, II, and I in various concentrations. Full Synthetics are comprised of Groups III, IV, and V oils. Purists like me would tell you that a full synthetic should only be Group IV or V, but thanks to a BS legal ruling about a decade ago in Castrol's favor, in the USA they are allowed to advertise a blend of Group III or higher as full synthetic. This isn't the case in the rest of the world btw.
The main reason the Harley blend isn't recommended for the trans and primary and the SYN3 is has to do with the additive package. Harley, and subsequently the others like Amsoil, Mobil 1, etc., threw in special antiwear additives for gears that aren't normally part of regular motor oil specifications. For those of us who don't buy into the one size fits all marketing hype it really doesn't matter because we use proper lubes for each hole rather than the same stuff in all three. Trans lube in the trans, gear and chain lube in the primary, and motor oil in the engine.
Jerry