Regarding ergo's, as others have mentioned, everyone is different and the MOCO probably has the mathematical overall average pretty well covered. While someone could certainly look at developing some degree of adjustability, the reality is, that's pretty tough when thinking about the bar heights, for example.
The point is, once you get a feel for where YOU personally differ from this 'norm', whatever that might be, then you pretty well know upfront what you will probably need to adjust on a new bike - same or similar model. For instance, I'm 5'10" with ~33" reach, ~31" inseam, so while the seat and seatback are usually fine, I have switched to the reach bars, which are a little bit taller and pull back a bit too. That and adjusting the highway pegs a bit makes it perfect.
That known, when I get ready to buy a new one, at the last round of negotiations, I stick in the requirement that they swap the bars or anything else I know I'll need to fit me. Typically, they will handle those demands pretty readily to clinch a deal, at a much lower cost than you will face after delivery.
Obviously, if you are moving to a totally different model, you owe it to yourself to rent perhaps the Non-CVO version for a day or two to get a feel for where the fit isn't quite optimal.
My .02 fwiw.