I have read in several places - on this forum and elsewhere - that the valve springs in the 110" heads are too strong, and they place undue stress on the components of the valve train. The springs on the 103", 96", 88", etc. twin cams engines are not nearly as strong, and they don't place nearly as much stress on the valve train components... which means these engines don't experience nearly that rate of valve train-related failures as the 110" engines do.
The barely-good-enough-for-the-job HD lifters are often the first things to fail in a 110" engine... with disastrous consequences. That may explain why so many of us have chosen to get rid of the HD lifters and go with much better aftermarket lifters from various manufacturers who DON'T make stuff as cheaply as they possibly can to just get by. These non-HD lifter generally don't fail very often.
Another sore spot - finally addressed by the MoCo recently - were the POS INA caged cam bearings. Many of us have replaced these with the much better Torrington full-complement cam bearings that cost all of $20 and won't fail.
Yet another sore spot is the twin cam pressed-together cranks, which again are cheap and are just barely good enough to make it out of warranty. In the Evo and older engines, the cranks were not all one piece, and they could be disassembled in the field and rebuilt. But with the twin cam engines, the MoCo went to a much less-expensive pressed-together crank, which fails at a much higher rate and must be completely replaced rather than rebuilt. Perhaps the longer stroke of the 110" engine places too much stress on the cheap cranks, and the smaller displacement engines don't. Who knows?
I haven't replaced my crank with a better one that has been plugged, welded, trued, and balanced to run like a crank should - but that's something that really should be done if you plan to keep a 110" bike for a long time. I think it's money well invested.
I HAVE replaced the HD cam support plate and oil pump with much better Feuling components... just for peace of mind.
I've said many times that my engine must have built on a Thursday morning (after church night!) because I have not had any problems with it at all in nearly 20,000 "spirited" miles. But perhaps that has as much to do with all of the parts I've replaced on Honey Badger as it does with the quality of my particular 110" engine specimen.
Ken